As Kimbo Slice, Ferguson worked as a bodyguard for RK Netmedia, a Miami-based adult entertainment responsible for number of popular adult subscription websites, such as MILF Hunter. Rolling Stone called Slice "The King of the Web Brawlers".
Slice made his sanctioned MMA debut against former WBO Heavyweight champion boxer Ray Mercer at Cage Fury Fighting Championships 5, in Atlantic City on June 23, 2007. The match was scheduled as a three-round exhibition utilizing all professional rules of MMA combat. Slice defeated Mercer with a guillotine choke at 1:12 into the first round.
In a post-fight interview, Slice stated that he would like to fight David "Tank" Abbott. Abbott, who was a spectator, stood up from his seat and accepted the call out. One of the matchmakers for CFFC asked Slice for his assurance so that an October 12th bout at Cage Fury Fighting Championships 6 between Slice and "Tank" Abbott could be organized. This event was later cancelled due to a promotion dispute.
On October 11, 2007, Proelite.com announced that they had signed Slice to a deal and that he would make his debut on the November 10 EliteXC. Originally set to make his professional MMA debut against Mike Bourke, the reformed street fighter was set to face Bo Cantrell after Bourke sustained a shoulder injury. Kimbo defeated Cantrell 19 seconds into the first round by submission due to punches.
Icey Mike Imber isn't only one of Kimbo's best friends, but he has also managed Kimbo's career since the very beginning. Slice has revealed that he currently lives with his family in Miami, and is the father of six children: three girls and three boys.